Voice Actors
| Character | Japanese Voice Actor | English Voice Actor |
| Vincent Valentine | Shougo Suzuki | Steve Blum |
| Shelke Rui | Fumiko Orikasa | Kari Wahlgren |
| Shalua Rui | Yuu Asakawa | Kim Mai Guest |
| Reeve Tuesti | Banjō Ginga | Jamieson Price |
| Cait Sith | Hideo Ishikawa | Greg Ellis |
| Weiss | Jouji Nakata | Dave Boat |
| Nero | Ryotaro Okiayu | Mike Rock |
| Azul | Tessho Genda | Brad Abrell |
| Rosso | Atsuko Tanaka | Mary Elizabeth McGlynn |
| Yuffie Kisaragi | Yumi Kakazu | Mae Whitman |
| Cid Highwind | Kazuhiro Yamaji | Chris Edgerly |
| Cloud Strife | Takahiro Sakurai | Steve Burton |
| Tifa Lockheart | Ayumi Ito | Rachael Leigh Cook |
| Barret Wallace | Masahiro Kobayashi | Beau Billingslea |
| Grimoire Valentine | Jouji Nakata | Bob Joles |
| Lucrecia Crescent | Rio Natsuki | April Stewart |
| Hojo | Nachi Nozawa | Paul Eiding |
| Genesis (G) | Gackt | Robin Atkin Downes |
| Restrictor (only in multiplayer) |
Hikaru Midorikawa |